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Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape
2020
Nature Communications
Antigenic drift of influenza virus hemagglutinin (HA) is enabled by facile evolvability. However, HA antigenic site B, which has become immunodominant in recent human H3N2 influenza viruses, is also evolutionarily constrained by its involvement in receptor binding. Here, we employ deep mutational scanning to probe the local fitness landscape of HA antigenic site B in six different human H3N2 strains spanning from 1968 to 2016. We observe that the fitness landscape of HA antigenic site B can be
doi:10.1038/s41467-020-15102-5
pmid:32144244
pmcid:PMC7060233
fatcat:x5fjjbkeqjb7nmxnhbzsfqbgqa