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Pain is a complex phenomenon involving interconnected physiological and psychological mechanisms. This complexity is a challenge for scientists and clinicians who have to deal with anatomical, physiological, cognitive, and affective pain components. The nociceptive signal coming from an injury will follow peripheral and central nervous pathways, but will also be modulated by endogenous mechanisms that will increase or reduce the signal and the perceived pain. It is for this reason that wedoi:10.3389/fpain.2020.574370 fatcat:cn3hx4tgijhkrhq7qvw6d3dvz4