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Pericentromeric Satellite III transcripts induce etoposide resistance
Cell Death and Disease
AbstractNon-coding RNA from pericentromeric satellite repeats are involved in stress-dependent splicing processes, maintenance of heterochromatin, and are required to protect genome stability. Here we show that the long non-coding satellite III RNA (SatIII) generates resistance against the topoisomerase IIa (TOP2A) inhibitor etoposide in lung cancer. Because heat shock conditions (HS) protect cells against the toxicity of etoposide, and SatIII is significantly induced under HS, we hypothesizeddoi:10.1038/s41419-021-03810-9 pmid:34031359 fatcat:rqvslwkjpngufdpt33nr3hskpi