The objective of the present study was to assess the oral-health-related quality of life (OHRQoL) of oral submucous fibrosis (OSMF) patients. A convenient sampling technique was used to recruit the clinically diagnosed patients of OSMF (n = 50). Based on the medical treatment, the patients were randomly divided into two study groups (group A and B). The group A patients received hyaluronidase (1500 IU) and Group B patients received submucosal intralesional injections of dexamethasone (2 mL; 4

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... /mL). Both the group A and B patients received respective medical therapy biweekly for a period of ten weeks. At the follow up visit (3 months), the impact of treatment on OHRQoL was assessed using the Oral Health Impact Profile-14(OHIP-14). Data were analyzed by a chi-square test for quantitative variables and an independent t-test for qualitative variables. The comparison of all clinical parameters before and after treatment was performed by a paired t-test. The results after treatment showed that there was a significant improvement in all domains of OHIP-14 except psychological disability. In addition, the OHRQoL of patients was significantly improved following the treatment.