Gene silencing and large-scale domain structure of the E. coli genome

Mina Zarei, Bianca Sclavi, Marco Cosentino Lagomarsino
2013 Molecular Biosystems  
The H-NS chromosome-organizing protein in E. coli can stabilize genomic DNA loops, and form oligomeric structures connected to repression of gene expression. Motivated by the link between chromosome organization, protein binding and gene expression, we analyzed publicly available genomic data sets of various origins, from genome-wide protein binding profiles to evolutionary information, exploring the connections between chromosomal organization, genesilencing, pseudo-gene localization and
more » ... ntal gene transfer. We report the existence of transcriptionally silent contiguous areas corresponding to large regions of H-NS protein binding along the genome, their position indicates a possible relationship with the known large-scale features of chromosome organization.
doi:10.1039/c3mb25364c pmid:23412141 fatcat:wjxodwomzvghfdjkrgtfwdp4se