Assessment of inflammation and risk of bladder tumour in adult male smokers in Nnewi, Nigeria

Manafa PO, Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria, Nwakor Justin C, Okeke CO, Aneke JC, Nwene EK, Ibeh NC, Chukwuma GO, Ogbuowelu SO, Ihim AC, Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria, Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria (+6 others)
2017 The Journal of Medical Research  
Cigarette smoking is a major risk factor in the development of several diseases. C-reactive protein is an acute phase protein of hepatic origin and the plasma concentration increases during inflammatory states while bladder tumour antigen is a complement factorH related protein(CFHrp) produced by bladder tumours. Study design: This is a case-control study designed to assess the levels of C-reactive protein and bladder tumor antigen in adult male smokers in Nnewi metropolis, Anambra state,
more » ... nambra state, Nigeria. Methods: A total of 100 subjects were recruited for the study. These comprised 50 adult male smokers and 50 adult male non-smokers. C-reactive protein and bladder tumour antigen levels were estimated by enzyme-linked immunosorbent assay technique. Ethical approval and informed consent were obtained before the commencement of the study. Statistical Package for Social Sciences version 20 was used for data analysis. Result: The result shows that there was a significant increase in the mean serum levels of bladder tumor antigen and C-reactive protein in adult male cigarette smokers compared with the control group (p<0.05).A positive correlation existed between c-reactive protein level and age in adult male smokers (r= 0.100,p=0.517). Similarly, a positive relationship was observed between c-reactive protein level and duration of smoking (r=0.082,p=0.598). Furthermore,a positive relationship was observed between bladder tumor antigen level in adult male smokers and age (r= 0.044,p=0.843). Conversely,an inverse relationship existed between bladder tumor antigen levels and duration of smoking (r=-0.180,p=0.411). Conclusion: Therefore smokers are predisposed to increased inflammation and heightened risk of bladder tumour.
doi:10.31254/jmr.2017.3407 fatcat:p6bwy5qmjbgvtjyn4stfieb3we