Principles for designing synthetic microbial communities

Nathan I Johns, Tomasz Blazejewski, Antonio LC Gomes, Harris H Wang
2016 Current Opinion in Microbiology  
Advances in synthetic biology to build microbes with defined and 20 controllable properties are enabling new approaches to design and program multispecies communities. This emerging field of synthetic ecology will be important for many areas of biotechnology, bioenergy and bioremediation. This endeavor draws upon knowledge from synthetic biology, systems biology, microbial ecology and evolution. Fully realizing the potential of this discipline 25 requires the development of new strategies to
more » ... trol the intercellular interactions, spatiotemporal coordination, robustness, stability and biocontainment of synthetic microbial communities. Here, we review recent experimental, analytical and computational advances to study and build multispecies microbial communities with defined functions and behavior for various 30 applications. We also highlight outstanding challenges and future directions to advance this field. 35
doi:10.1016/j.mib.2016.03.010 pmid:27084981 pmcid:PMC4899134 fatcat:7lgpy7kskvhpbhx5cb2gpxgl5m