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Journal of Chemical and Pharmaceutical Research
Blood clots are formed from fibrinogen by thrombin and are lysed by plasmin, which is activated from tissue plasminogen activator. It was developed for the treatment of thrombosis because of its efficacy and strong affinity to fibrin. Due to the expense and undesirable side effects such as gastrointestinal bleeding, allergic reaction, and resistance to repercussion. Therefore the search for thrombolytic agents from other source is needed. Production of fibrinolytic enzyme from Bacillus subtilisfatcat:g3bbf6v4dffcjckmbm2x3nnxgq