FEBS PLC2016 Ligand-binding course Lec tures-Mon day, July 4 L1 INTRODUCTION TO LIGAND-BIND ING THE ORY I L2 PROBLEM-SOLVING AND GLOBAL ANALYSIS COMPUTATIONAL EXERCISES LI GAND BIN DING IN MO DERN DRUG DIS CO VE RY

Jannette Carey, Wei-Feng Xue, Pres Ton Hensley
unpublished
De part ment of chem is try, Prince ton Uni ver sity, Frick Lab o ra tory, 360 Prince ton, NJ 08544, USA The lec tures are in tended to equip stu dents with the fol lowing skills that can be ap plied equally to their own bind ing data or to pub lished data: use the prin ci ples of equi lib rium, mass ac tion, and mass bal ance to de rive equa tions de scrib-ing bind ing pro cesses; cor rectly plot bind ing data; use graph i cal anal y sis to in ter pret bind ing data; cal cu late predicted bind
more » ... ing iso therms; sim u late and fit bind ing iso-therms; de ter mine and quan tify af fin ity, stoichiometry, and cooperativity of bind ing pro cesses; quan tify, di ag nose, and eval u ate ran dom and sys tem atic er rors in bind ing data. The lec tures will in clude com pu ta tional ex er cises. Two work shop ses sions will dem on strate the workflow of ligand-bid ing data anal y sis. The first work shop will con-sol i date the ba sic the ory of ligand-bid ing mod els and how mod els are used in bind ing-data anal y sis. The sec ond work shop will in tro duce the con cept of ad vanced global anal y sis of ligand-bind ing data. Op por tu nity will also be avail able for stu dents to ana lyse their own protein-ligand binding data. Lectu res-Tue sday, July 5 L3 IN TRO DUCTI ON TO LI GAND-BIN DING THE O RY II Jan nette Ca rey De part ment of chem is try, Prince ton Uni ver sity, Frick Lab o ra tory, 360 Prince ton, NJ 08544, USA Ó Krystalografická spoleènost b10 FEBS Ad vanced Course Ligand-bind ing-Lec tures Ma te ri als Struc ture, vol. 23, no. 2b (2016) Ó Krystalografická spoleènost Ma te ri als Struc ture, vol. 23, no. 2b (2016) FEBS Ad vanced Course Ligand-bind ing b15 Lectu res-Sa tur day, July 9 L16 OVERVIEW OF THE PRACTICAL METHODS Jan nette Ca rey De part ment of chem is try, Prince ton Uni ver sity, Frick Lab o ra tory,
fatcat:g5dcvobrsfautbq7rp7crgiyem