Objective: To analyze the indications, frequency and outcomes of open partial cholecystectomy in comparison with complete cholecystectomy during surgery. Material & Methods: A retrospective descriptive study was performed at the Department of Surgery, BaqaiMedical University Hospital, Nazimabad, Karachi from April 2007 to April 2012. A total number of 42 patients with gall stone disease, who underwent partial cholecystectomy, were analyzed. The case selection criteria wasbased preoperatively on

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... history, clinical findings, ultrasound and CT scan examination. Final decision was madeas per operative findings during open cholecystectomy. Results: Forty-two (42) patients with gall stone disease underwent partial cholecystectomy. Age range was from35 years to 80 years (Mean age: 47 years). Male and female ratio showed female preponderance.In our study,62% patients had acute cholecystitis, 16.5% patients had empyema gall bladder, 9.5% patients had mucoceleand 12% patients had gall stone acute pancreatitis. Tube Cholecystostomy was performed in two patients. Conclusion: Partial cholecystectomy is safe and effective procedure in difficult cases, with overall less complications and is almost equivalent to total cholecystectomy.0