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3-Deazaadenosine, aS-Adenosylhomocysteine Hydrolase Inhibitor, Has Dual Effects on NF-κB Regulation
1999
Journal of Biological Chemistry
Previously we reported that 3-deazaadenosine (DZA), a potent inhibitor and substrate for S-adenosylhomocysteine hydrolase inhibits bacterial lipopolysaccharideinduced transcription of tumor necrosis factor-␣ and interleukin-1 in mouse macrophage RAW 264.7 cells. In this study, we demonstrate the effects of DZA on nuclear factor-B (NF-B) regulation. DZA inhibits the transcriptional activity of NF-B through the hindrance of p65 (Rel-A) phosphorylation without reduction of its nuclear
doi:10.1074/jbc.274.27.18981
pmid:10383397
fatcat:k3ogqi6agfg2dnf7d3l45xuuzy