Immunoglobulin G4-associated to multiorganic lymphoproliferative disease
Enfermedad linfoproliferativa multiorgánica asociada a inmunoglobulina G4

María T Bourlon, Mónica Chapa, Fredy Chablé Montero, Jorge Hernández Calleros
Gaceta Médica de México  
We report a case of a woman with lymphoproliferative multiorganic immunoglobulin G4 (IgG4) related disease with extensive involvement showing dacryoadenitis, sialoadenitis, parotiditis, pancreatitis, pneumonitis, lymphadenopathy and immune thrombocytopenic purpura. Serum elevation of acute phase reactant, polyclonal hypergammaglobulinemia, positivity for antinuclear antibodies and rheumatoid factor was found. Hystologically plasma cell infiltration was demonstrated on glandular and lymphatic
more » ... sue and immunochemistry was positive for IgG4 in > 30%. Immunosuppressive treatment with steroids and azathioprine was given with an excellent clinical response, the marked radiologic evidence of improvement and the decrease in inflammatory makers that conducted to symptom remission are shown in the text.
pmid:22116188 fatcat:rmcu2fvt7fbfvlrutvnhdgt5a4