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A Comprehensive Review on Current Advances in Peptide Drug Development and Design
2019
International Journal of Molecular Sciences
Protein–protein interactions (PPIs) execute many fundamental cellular functions and have served as prime drug targets over the last two decades. Interfering intracellular PPIs with small molecules has been extremely difficult for larger or flat binding sites, as antibodies cannot cross the cell membrane to reach such target sites. In recent years, peptides smaller size and balance of conformational rigidity and flexibility have made them promising candidates for targeting challenging binding
doi:10.3390/ijms20102383
fatcat:wjv3k734yrbsrncqok2i5lj7ym