Diagnostic value of exhaled nitric oxide and bronchial challenge tests

A. A. Meliashkevich, P. Ahrens, V. Gerein
2005 Russian Pulmonology  
The reported practical work shows a significance of detection the exhaled fraction of nitric oxide (FENO) compared with bronchial challenge tests to diagnose the allergic inflammation and to determine the inflammatory activity in the airways. Methods: 30 bronchial challenge tests were performed in 24 children aged 5 to 16 yrs with different degrees of sensitization detected by the prick-test. The challenge tests were performed with various allergens, the lung function was examined by spirometry
more » ... or pneumotachometry, the airway resistance was studied by impulse oscillometry. The FENO was measured using a chemiluminescent gas analyzer. The FENO levels obtained after the challenge tests allowed to divide the patients with positive test results in 2 groups and those with negative test results in 3 groups. Two negative and the positive groups had the similar FENO levels and only the third negative group had different FENO level. Therefore, the FENO allows detecting the allergy imflammation including its latent form even if the challenge test is negative.
doi:10.18093/0869-0189-2005-0-3-59-65 fatcat:5inv74mrhng55nn5ic4u4od4im