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INTERNATIONAL JOURNAL OF PHARMACEUTICAL, CHEMICAL AND BIOLOGICAL SCIENCES SYNTHESIS, CHARACTERISATION AND BIOLOGICAL ACTIVITY OF SOME NOVEL AZETIDINONES FROM NAPHTHO [2,1-b]THIOPHENE
IJPCBS
unpublished
The reaction of ethyl naphtho[2,1-b]thiophene-2-carboxylate 2 with hydrazine hydrate produced naphtho[2,1-b]thiophene-2-carbohydrazide 3 which upon treatment with various aromatic aldehydes produced Schiff bases i.e. N-(aryl-methylene) substitutednaphtho[2,1-b]thiophene-2carbohydrazides 4a-f which served as an excellent intermediate for the synthesis of titled compounds. The Schiff bases 4a-f readily underwent cyclisation upon reaction with chloroacetyl chloride in presence of triethyl amine to
fatcat:ukw6ktittfcgfdqcixslci4zp4