Purpose: This study investigated factors affecting Quality of Life (QoL) of patients with Meniere disease. Methods: A descriptive study design was used. Data were collected from March to April 2020 through an online survey of 130 participants diagnosed with probable or definite Meniere disease from a community of online-based patients. The data were analyzed using the independent t-test, Pearson's correlation coefficient, and multiple linear regression analysis. Results: Perceived health,

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... y, depression, family support, and health care provider support significantly correlated with QoL. As a result of the multiple regression analysis, family support, perceived health, anxiety, and ear fullness were identified as factors influencing QoL, and these factors accounted for 65.0% of the variance in QoL. Of these variables, family support was the factor affecting the participants' QoL the most (β=.45). Conclusion: These results indicate a need for continuous efforts and strategies to increase family support to enhance the QoL of this population. In addition, to increase perceived health (which was the second most influencing factor on the QoL of this population), improved health care provider support (which showed a positive correlation with perceived health) is also warranted. Therefore, nursing interventions aiming to increase social support should be developed and implemented.