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The estrogen receptor a (ERa) regulates gene expression by either direct binding to estrogen response elements or indirect tethering to other transcription factors on promoter targets. To identify these promoter sequences, we conducted a genome-wide screening with a novel microarray technique called ChIP-on-chip. A set of 70 candidate ERa loci were identified and the corresponding promoter sequences were analyzed by statistical pattern recognition and comparative genomics approaches. We founddoi:10.1093/nar/gkh1005 pmid:15608294 pmcid:PMC545447 fatcat:n6h5qhjijbaqtbvb5mgm7vfhaa