Dilatation of the Ductus Arteriosus by Diazoxide in Fetal and Neonatal Rats [chapter]

Katsuaki Toyoshima, Kazuo Momma, Tetsuko Ishii, Toshio Nakanishi
2020 Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension  
Keywords Diazoxide · Ductus arteriosus · Rat Background We previously reported that ATP-sensitive potassium (K ATP ) channels regulate ductal constriction in response to oxygen [1]. Diazoxide is a K ATP channel opener while the usefulness of diazoxide for hyperinsulinemic hypoglycemia is well established. Yoshida et al. reported DA reopening in very low-birth-weight infants [2] . The objectives of this study were to elucidate the effect of K ATP channel openers on the DA in neonatal rats as
more » ... as the different effects in preterm and full-term fetal rats [3]. Methods Near-term rat pups delivered via a cesarean section were housed at 33 °C. After rapid whole-body freezing, the ductus arteriosus (DA) diameter was measured using a microscope and a micrometer. Full-term pregnant rats (gestational day 21) were
doi:10.1007/978-981-15-1185-1_43 fatcat:ez2g5x4vqvbkjgia2hlaao6s54