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The effects of mutational processes and selection on driver mutations across cancer types
2018
Nature Communications
Epidemiological evidence has long associated environmental mutagens with increased cancer risk. However, links between specific mutation-causing processes and the acquisition of individual driver mutations have remained obscure. Here we have used public cancer sequencing data from 11,336 cancers of various types to infer the independent effects of mutation and selection on the set of driver mutations in a cancer type. First, we detect associations between a range of mutational processes,
doi:10.1038/s41467-018-04208-6
pmid:29748584
pmcid:PMC5945620
fatcat:mwkit4m3jfbgpe7unsikhn5gqi