Electrophysiologically detailed models of the right and left rabbit atria: Pharmacological impacts on propagation and arrhythmogenesis

O.V. Aslanidi, R.S. Dewey, A.R. Morgan, M.R. Boyett, H. Zhang
2008 2008 Computers in Cardiology  
Experimentally observed differences in the action potential (AP) properties -primarily, refractorinessbetween the left (LA) and right (RA) atria are believed to be important in maintaining atrial fibrillation (AF). However, relationships between the underlying ionic differences in the LA and RA cells, as well as their impacts on the tissue refractoriness and susceptibility to AF are unknown. We quantify such relationships by developing detailed AP models for LA and RA, studying refractory and
more » ... ng refractory and vulnerable properties of both tissues, and pharmacological impacts controlling them.
doi:10.1109/cic.2008.4748979 fatcat:ttojq7m7m5hyro2mrm2fpznzji