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We present genetic analyses of murine weight loss during dietary restriction (DR) for females eating 60 % ad libitum (AL). We examined five cohorts across 81 different strains (22 strains tested twice) that included the LXS and LSXSS recombinant inbred strains, the LXS parental strains ILS and ISS, and the classical inbreds 129S6, A, BALB/c, C57BL/6, C3H, and DBA. Weight loss exhibited highly significant genetic variation, with DR body weights ranging from ~60% to ~85% of AL body weight. Thisdoi:10.1152/physiolgenomics.00068.2006 pmid:16849633 fatcat:vovvftw5mnclrh7vgudx4lh6jm