Advances in Pharmacognosy and Phytomedicine Antibacterial and Antioxidant Activities of Essential Oil of Inula Viscosa L. from Northwest of Algeria ARTICLE INFO ABSTRACT
Advances in Pharmacognosy and Phytomedicine
Inula viscosa has been used for years in folk medicine for its anti-inflammatory, antipyretic, antiseptic, and paper antiphlogistic activities. The aim of the present study is to investigate the antibacterial and antioxidant activities of the essential oils extracted by hydrodistillation from the leaves of Inula viscosa Ait., which was collected from Mohammadia region near Mascara city in the Northwest of Algeria. Antibacterial activity of the essential oils against Escherichiacoli and
... iacoli and Staphylococcus aureus, was tested using the agar well-diffusion method and disc diffusion technique by determining the inhibition zone, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The results of the diffusion methods showed that the oils had strongest antibacterial activity with inhibition zones ranged between 14-33 mm against S. aureus. The MIC and MBC were respectively 4.17 µl /ml and 8.32 µl /ml on S. aureus, in contrast, Escherichiacoli was resistant to the essential oil. Antioxidant activity was determined by in vitro tests using a quantitative DPPH (1,1-diphenyl-2-picryl hydrazyl) assay. I. viscosa oil exhibited effective radical scavenging capacity compared to the positive control (ascorbic acid) with 50% inhibitory concentration (IC50) of 0.16 mg/mL. These results could support the use of plant by traditional healers to treat various infective diseases. These properties indicate the possibility of exploitation of essential oil of I. viscosa for food and pharmaceutical industries.