Diffusion-weighted magnetic resonance imaging is a non-invasive imaging method that has been increasingly used in neuroscience imaging over the last decade. Partial volume effects (PVEs) exist in sampling signal for many physical and actual reasons, which lead to inaccurate fiber imaging. We overcome the influence of PVEs by separating isotropic signal from diffusion-weighted signal, which can provide more accurate estimation of fiber orientations. In this work, we use a novel response function

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... (RF) and the correspondent fiber orientation distribution function (fODF) to construct different signal models, in which case the fODF is represented using dictionary basis function. We then put forward a new index P iso , which is a part of fODF to quantify white and gray matter. The classic Richardson-Lucy (RL) model is usually used in the field of digital image processing to solve the problem of spherical deconvolution caused by highly ill-posed least-squares algorithm. In this case, we propose an innovative model integrating RL model with spatial regularization to settle the suggested double-models, which improve noise resistance and accuracy of imaging. Experimental results of simulated and real data show that the proposal method, which we call iRL, can robustly reconstruct a more accurate fODF and the quantitative index P iso performs better than fractional anisotropy and general fractional anisotropy. Results Optimal regularization parameter. The new deconvolution algorithm with TV and ℓ 1 regularization has shown good imaging result with the elaborately chosen regularization iRL PLOS ONE |