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COMT Val158Met Polymorphism Exerts Sex-Dependent Effects on fMRI Measures of Brain Function
2017
Frontiers in Human Neuroscience
Evidence suggests that dopamine levels in the prefrontal cortex (PFC) modulate executive functions. A key regulator of PFC dopamine is catechol-O-methyltransferase (COMT). The activity level of the COMT enzyme are influenced by sex and the Val 158 Met polymorphism (rs4680) of the COMT gene, with male sex and Val alleles both being associated with higher bulk enzyme activity, and presumably lower PFC dopamine. COMT genotype has not only been associated with individual differences in frontal
doi:10.3389/fnhum.2017.00578
pmid:29270116
pmcid:PMC5723646
fatcat:n2cxer5wengbzlsvkcm424xxza