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SITE DIRECTED MUTAGENESIS OF HUMAN INTERLEUKIN-2 GENE TO INCREASE THE STABILITY OF THE GENE PRODUCT- A BIOINFORMATICS APPROACH
English
2009
International Journal of Bioinformatics Research
English
Interleukin-2 (IL-2) is an immunoregulatory cytokine whose biological effects are mediated through interaction with specific receptors on the surface of target cells. Due to its presumed role in generating a normal immune response, IL-2 is being evaluated for the treatment of a variety of tumors, in addition to infectious diseases. Main drawback of human IL-2 is that the molecule is relatively unstable. Therefore, with the objective of increasing the stability of the molecule, site directed
doi:10.9735/0975-3087.1.2.4-13
fatcat:yr4emfnwiraprlwbhdym2burnu