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Spiroindolines Identify the Vesicular Acetylcholine Transporter as a Novel Target for Insecticide Action
2012
PLoS ONE
The efficacy of all major insecticide classes continues to be eroded by the development of resistance mediated, in part, by selection of alleles encoding insecticide insensitive target proteins. The discovery of new insecticide classes acting at novel protein binding sites is therefore important for the continued protection of the food supply from insect predators, and of human and animal health from insect borne disease. Here we describe a novel class of insecticides (Spiroindolines)
doi:10.1371/journal.pone.0034712
pmid:22563457
pmcid:PMC3341389
fatcat:kxubk46xtzd5lc5b664kakzbrq