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AbstractPyruvate dehydrogenase kinase family of enzymes (PDK1-4) are central negative regulators of the TCA cycle by phosphorylating the rate-limiting multi-enzyme pyruvate dehydrogenase complex (PDC). Here, we show that the PDK family is dispensable for murine embryonic development and that BCKDK serves as a compensatory mechanism for PDKs by inactivating PDC.To study the role of Pdk family in vivo, we knocked out all four genes one by one. Surprisingly, Pdk total KO mouse embryos developeddoi:10.1101/2020.03.22.002360 fatcat:ouvigr3wevdjxi3nbz7jnea2fu