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Ruta graveolens is important medicinal and aromatic plant of pharmaceutical value. To meet the industrial requirements and optimize production and decrease cost of seedlings, the bioreactor helps lot. The main aim of this work was to compare in vitro cultivation of Ruta graveolens. L different systems of liquid culture with simple aerated bioreactors. The in vitro growth of the shoots was promoted in traditional system and in aerated bioreactor. Both propagation systems used the basic MS liquidfatcat:lab5xo6ynrbufglcivwsnouqmi