Abstract

Mike van der Wal, Scott A. Lang, Ray W. Yip, Frances L. Chow, Peter G. Duncan, Robert A. Perverseff, Lesley-Ann L. Crone, Robert A. Verity, Jim Flath, David L. Twist, William E. Code, Jim Thornhill (+345 others)
1993 Canadian Journal of Anesthesia  
INTRQDUCTION: Opiates are hypothesized to cause a vasodepressor effect by acting on the rostral vantrolateral medulla (RVLM) wherein lie neurons which control sympathetic tone. Using voltammetry which measures catecholamine oxidation currents (CA.OC) generated by adrenergic activity in these neurons, our objective was to demonstrate the in vivo effect of morphine on the RVLM. METHODS: Halothane anaesthetized rats were implanted stereotaxically with carbon-fibre electrodes to monitor CA-OC by
more » ... monitor CA-OC by differential normal pulse voltammetry. Mean arterial pressure (MAP) was monitored by a femoral arterial line. After stabilization, rats received either intracerebroventricular (icy) morphine 10/zg (n =5) followed 45 minutes later by intravenous (iv) naloxone 1 mg-kg" or icy saline 5/Jl (n=5) followed by iv saline 0.45 ml. Changes in MAP and CA. OC were compared to baseline. REFERENCES= i.
doi:10.1007/bf03020692 fatcat:teoswhi2yfeodc5c6p2twajnwm