Background. World Health Organization (WHO) has recommended oxytocin as an optional uterotonic medicine to prevent and handle postpartum haemorrhage. However, there is much worry about the quality of oxytocin in developing countries. Aim: To describe the condition of oxytocin cold chain in the peripheral area, from the source until before being applied to the patients. Method. Mixed method with sequential exploratory strategy was used in this study. Qualitative design used phenomenological

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... ach and quantitative method used cross-sectional approach. Data collecting was done through in-depth interviews using interview guidelines. Participants were oxytocin suppliers, persons in charge of drug warehouses in medical centres, and medical personnels helping childbirth. Samples were selected using purposive sampling. Data collecting was done from November 2017 to February 2018 in Indragiri Hilir Regency, the Province of Riau, Indonesia. There were 32 participants getting involved in in-depth interviews, 123 respondents filled in questionaires and all were verified using supporting data. Results. Findings of this study describe oxytocin cold chain including drugstores, delivery process, duration of delivery, oxytocin handling, oxytocin orders, kinds of medicine, medicine chests, and electricity in medicine supliers, drug warehouses and medical centres. Conclusion. Most of the cold chain of oxytocin is not maintained from drug suppliers, drug warehouses, health care providers to the patients. Deviation tolerance of oxytocin cold chain can not be used as a justification. There is a consequence of oxytocin potential decline for every deviation. The government should examine unregistered and below standard medicine manufacturers, and encourage law enforcement for every violation.