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Arterial gene transfer of acidic fibroblast growth factor for therapeutic angiogenesis in vivo: critical role of secretion signal in use of naked DNA
Objective: Previous studies have demonstrated that arterial gene transfer of naked DNA encoding for a secreted protein may permit Ž . modulation of the host phenotype despite a low transfection efficiency. Acidic fibroblast growth factor aFGF is an angiogenic growth factor, but is not secreted by intact cells. In the current study, we investigated the hypothesis that addition of a hydrophobic leader sequence to achieve active secretion of the gene product would permit therapeutic angiogenesisdoi:10.1016/s0008-6363(97)00152-1 pmid:9415291 fatcat:6wacroc2rjfydactrnbszrvc3q