Objective: The aim of our study was to determine the prevalence of smoking and its impact on the various parameters of spondyloarthritis based on collected data from the Moroccan biotherapy register. Materials and methods: This is a multicenter study based on data from the Moroccan biotherapy register related to patients suffering from spondyloarthritis. An analysis of the socio-demographic parameters as well as an evaluation of the variables associated with the disease were performed.

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... e and multivariate logistic regressions were conducted to assess what the impact of smoking is on the various spondyloarthritis parameters. p<0.05 was set to be the significant threshold. Results: The study is based on data collected from 194 patients (21 smokers and 173 non-smokers) suffering from AS included in the Moroccan biotherapy register. The prevalence of smoking was 10.8%. Male gender was associated with smoking (63% of men in non-smoking group versus 90% of men in the smoking group) (p = 0.006). In addition, a higher CRP: 8 [2-17] was observed in the smoking group compared to 5.5 in the non-smoking group (p = 0.048). No significant difference between the 2 groups was statistically noted in terms of the disease activity evaluated by the BASDAI and ASDAS CRP score which were respectively 2.77 +/-1.82 and 2.25 ± 1.66 in the smoking group and 3.24 +/-2.15 and 2.09 ± 1.7 in the non-smoking one. Furthermore, our results did not reveal a significant correlation between smoking and the functional impact of spondyloarthritis. No correlation was established between smoking and the structural progression of the disease. Conclusion: Our study suggests that male gender and a higher CRP are statistically associated with tobacco consumption. Larger scale studies are needed to support these results.