Clinical utility of pharmacogenetic biomarkers in cardiovascular therapeutics: a challenge for clinical implementation

Frank S Ong, Joshua L Deignan, Jane Z Kuo, Kenneth E Bernstein, Jerome I Rotter, Wayne W Grody, Kingshuk Das
<span title="">2012</span> <i title="Future Medicine Ltd"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/gcfq53ko6fekjbl4whca5egjki" style="color: black;">Pharmacogenomics (London)</a> </i> &nbsp;
In the past decade, significant strides have been made in the area of cardiovascular pharmacogenomic research, with the discovery of associations between certain genotypes and drug-response phenotypes. While the motivations for personalized and predictive medicine are promising for patient care and support a model of health system efficiency, the implementation of pharmacogenomics for cardiovascular therapeutics on a population scale faces substantial challenges. The greatest obstacle to
more &raquo; ... l implementation of cardiovascular pharmacogenetics may be the lack of both reproducibility and agreement about the validity and utility of the findings. In this review, we present the scientific evidence in the literature for diagnostic variants for the US FDA-labeled cardiovascular therapies, namely CYP2C19 and clopidogrel, CYP2C9/ VKORC1 and warfarin, and CYP2D6/ADRB1 and β-blockers. We also discuss the effect of HMGCR/LDLR in decreasing the effectiveness of low-density lipoprotein cholesterol with statin therapy, the SLCO1B1 genotype and simvastatin myotoxicity, and ADRB1/ADD1 for antihypertensive response. In the past decade, significant strides have been made in the area of cardiovascular pharmacogenomic research, with the discovery of association between certain genotypes and
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2217/pgs.12.2">doi:10.2217/pgs.12.2</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22380001">pmid:22380001</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3306231/">pmcid:PMC3306231</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/uwgz5wrmlfhvflqbwivz4tgixu">fatcat:uwgz5wrmlfhvflqbwivz4tgixu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190303021720/http://pdfs.semanticscholar.org/ad8c/3603122a245ec60eff992498ed879a8f37f3.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ad/8c/ad8c3603122a245ec60eff992498ed879a8f37f3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2217/pgs.12.2"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306231" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>