THE EFFECT OF EXPERIMENTAL CHLORINE POISONING ON CERTAIN AMINO ACIDS AND ENZYMES IN RATS, FED ON RICH PROTEIN RATION

V Boyadjiev, L Halacheva, I Denev
unpublished
Although acute occupational chlorine poisonings have been thoroughly investigated, the problem of chronic intoxications is still not fully clarified. The latter assumes great importance under the acutal conditions of steadily expanding industrial production and utilization of chlorine in various spheres of present material living conditions. There is still insufficient data in the pertinent literature, concerning the clinical picture and changes in metabolite-catabolite processes during chronic
more » ... sses during chronic chlorine influencing. The increase of the non-specific total morbidity rate of the respiratory system among persons engaged in chlorine production is beyond any doubt. Some humoral changes are also recorded, such as reduction of the alkaline reserve and catalase of the blood, rise of bilirubin serum level etc. The organic and functional alterations observed are attributed to tissue destruction, subsequent to dehydrogenation of the tissue fluids. The more intimate effects, exerted upon the metabolic processes, respectively, the quantitative and qualitative changes in protein and amino acid content, are not fully clarified. The data available about the activity of the enzymes within the various biological substrates in chlorine poisoning are even less complete. The interest in the study of pathogenetic changes under the aspect thus outlined is justified by the necessity of discovering new biochemical tests for early diagnosis of the chronic effects of chlorine. On the other hand, the problem of prophylactical occupational nutrition of chlorine contact workers also awaits solution. After demonstrating the tissue-destructive action of chlorine, the question is posed about exo-genous influencing, without underestimating the limitations existing in this respect, of the protein-amino acid exchange by means of differentiated prophylactic and therapeutic-prophylactic nutritive diets in chronic effects of chlorine. The literature data and personal experience alike (1, 2, 3, 4, 5, 11) prove the significance of proteins as a protective factor in the occurrence and development of occupational intoxications. This effect is based on the quantitative and qualitative composition of the administered proteins. Insofar as chlorine is concerned, there are no investigations in this direction, except for the Soviet nutrituve ration No. 2 already adopted.
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