Metabolic Syndrome as an Independent Risk Factor of Silent Brain Infarction in Healthy People

H.-M. Kwon, B. J. Kim, S.-H. Lee, S. H. Choi, B.-H. Oh, B.-W. Yoon
2005 Stroke  
and Purpose-Metabolic syndrome (MetS) is associated with an increased risk of the subsequent development of cardiovascular disease or stroke. Moreover, a silent brain infarction (SBI) can predict clinical overt stroke or dementia. We examined the associations between SBI and MetS in apparently healthy individuals. Methods-We evaluated 1588 neurologically healthy subjects (927 males and 661 females) who underwent brain MRI at Seoul National University Hospital Healthcare System Gangnam Center.
more » ... m Gangnam Center. MetS was defined using the criteria of the National Cholesterol Education Program Adult Treatment Panel III. We examined associations between full syndrome (Ն3 of the 5 conditions) as well as its components and SBI by controlling possible confounders. Results-Eighty-eight (5.5%) were found to have Ն1 SBI on MRI. Age was found to be significantly related to SBI prevalence ( odds ratio [OR], 1.06; 95% CI, 1.04 to 1.09). A history of coronary artery disease was associated with an elevated odds ratio of SBI (OR, 2.83; 95% CI, 1.38 to 5.82), and MetS was significantly associated with SBI (OR, 2.18; 95% CI, 1.38 to 3.44). The components model of MetS showed a strong significance between an elevated blood pressure (OR, 3.75; 95% CI, 2.05 to 6.85) and an impaired fasting glucose (OR, 1.74; 95% CI, 1.08 to 2.80) and the risk of SBI. Conclusions-MetS was found to be significantly associated with SBI. This finding has clinical utility in terms of identifying healthy people at increased risk of developing SBI. (Stroke. 2006;37:466-470.)
doi:10.1161/01.str.0000199081.17935.81 pmid:16373631 fatcat:drb5zgpe6zbmrlgrz4j5rpzq3m