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Selinidin Suppresses IgE-Mediated Mast Cell Activation by Inhibiting Multiple Steps of FcεRI Signaling
Biological and Pharmaceutical Bulletin
IgE -mediated mast cell activation is critical for development of allergic inflammation. We have recently found that selinidin, one of the coumarin derivatives isolated from Angelica keiskei, attenuates mast cell degranulation following engagement of the high-affinity receptor for IgE (Fce e RI) with IgE and antigen. In the present study, we investigated the effects of selinidin on intracellular signaling and mast cell activation employing bone marrow-derived mast cells. Here, we report thatdoi:10.1248/bpb.31.442 pmid:18310907 fatcat:6sbzmfiayfdytboqrwyibfjkgy