Central auditory disorders: toward a neuropsychology of auditory objects

Johanna C Goll, Sebastian J Crutch, Jason D Warren
2010 Current Opinion in Neurology  
Purpose of review-Analysis of the auditory environment, source identification and vocal communication all require efficient brain mechanisms for disambiguating, representing and understanding complex natural sounds as 'auditory objects'. Failure of these mechanisms leads to a diverse spectrum of clinical deficits. Here we review current evidence concerning the phenomenology, mechanisms and brain substrates of auditory agnosias and related disorders of auditory object processing. Recent
more » ... Analysis of lesions causing auditory object deficits has revealed certain broad anatomical correlations: deficient parsing of the auditory scene is associated with lesions involving the parieto-temporal junction, while selective disorders of sound recognition occur with more anterior temporal lobe or extra-temporal damage. Distributed neural networks have been increasingly implicated in the pathogenesis of such disorders as developmental dyslexia, congenital amusia and tinnitus. Auditory category deficits may arise from defective interaction of spectrotemporal encoding and executive and mnestic processes. Dedicated brain mechanisms are likely to process specialised sound objects such as voices and melodies. Summary-Emerging empirical evidence suggests a clinically relevant, hierarchical and fractionated neuropsychological model of auditory object processing that provides a framework for understanding auditory agnosias and makes specific predictions to direct future work.
doi:10.1097/wco.0b013e32834027f6 pmid:20975559 pmcid:PMC3374998 fatcat:bguiu6dkxzadznpxweinu2yos4