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Convenient Synthesis of Some Novel 4-Benzyl-1(2H)-Phthalazinone Derivatives of expected anticancer activity
2019
Proceedings of The 23rd International Electronic Conference on Synthetic Organic Chemistry
unpublished
Series of new synthesized biologically active phthalazinone derivatives were obtained. Starting from the amino acid methyl esters of 4-benzyl-1(2H)phthalazinone 2a,b which were synthesized from the aceto hydrazide of 4-benzyl-1(2H)-phthalazinone 1 via azide coupling method. The hydrazides 3a,b were prepared from hydrazinolysis of corresponding esters 2a,b. N-substituted-2-(4-Benzyl-1-oxo-1H-phthalazin-2-yl)-methyl-acetamide 4a-f and the dipeptides methyl
doi:10.3390/ecsoc-23-06605
fatcat:ih6hhltpnfg2xah3t22gyv2b3y