Convenient Synthesis of Some Novel 4-Benzyl-1(2H)-Phthalazinone Derivatives of expected anticancer activity

Samir El Rayes, Ibrahim Ali, hamdy Abd Elazeem, Sara Eltorky
2019 Proceedings of The 23rd International Electronic Conference on Synthetic Organic Chemistry   unpublished
Series of new synthesized biologically active phthalazinone derivatives were obtained. Starting from the amino acid methyl esters of 4-benzyl-1(2H)phthalazinone 2a,b which were synthesized from the aceto hydrazide of 4-benzyl-1(2H)-phthalazinone 1 via azide coupling method. The hydrazides 3a,b were prepared from hydrazinolysis of corresponding esters 2a,b. N-substituted-2-(4-Benzyl-1-oxo-1H-phthalazin-2-yl)-methyl-acetamide 4a-f and the dipeptides methyl
more » ... -1H-phthalazin-2-yl)-acetylamino]-acetylamino}alkanoates 6a-c were obtained by the reaction of corresponding hydrazide 3a with amines and amino acid esters respectively via azide coupling method. Similarly; Nsubstituted -3-[2-(4-Benzyl-1-oxo-1H-phthalazin-2-yl)-acetyl amino] propionamide 5a-f and the dipeptides methyl{3-[2-(4-Benzyl-1-oxo-1Hphthalazin-2-yl)-acetylamino]-propionylamino} alkanoates 7a-c were obtained by the reaction of corresponding hydrazide 3b with amines and amino acid esters respectively via azide coupling method
doi:10.3390/ecsoc-23-06605 fatcat:ih6hhltpnfg2xah3t22gyv2b3y