Estimating Cure Rates From Survival Data

A. D Tsodikov, J. G Ibrahim, A. Y Yakovlev
2003 Journal of the American Statistical Association  
This article considers the utility of the bounded cumulative hazard model in cure rate estimation, which is an appealing alternative to the widely used two-component mixture model. This approach has the following distinct advantages: (1) It allows for a natural way to extend the proportional hazards regression model, leading to a wide class of extended hazard regression models. (2) In some settings the model can be interpreted in terms of biologically meaningful parameters. (3) The model
more » ... re is particularly suitable for semiparametric and Bayesian methods of statistical inference. Notwithstanding the fact that the model has been around for less than a decade, a large body of theoretical results and applications has been reported to date. This review article is intended to give a big picture of these modeling techniques and associated statistical problems. These issues are discussed in the context of survival data in cancer.
doi:10.1198/01622145030000001007 pmid:21151838 pmcid:PMC2998771 fatcat:3byf6lcynjhnndmvu6hgo6wyxi