Protective effect of trapidil andl-arginine against renal and hepatic toxicity induced by cyclosporine in rats

Neveen A. Salem, Emad A. Salem, Aref M. Maarouf, Mostafa Kamel, Hazem Elgalaly, Mohamed Radwan, Walid A. Abd El-Dayem, Mahmoud ElAdl
2010 Renal Failure  
Forty eight adult male of white albino rats (Sprague Dawley Strain) were injected by a single dose of potassium bromate at dose 130 mg/kg body weight intraperitoneal to induce renal toxicity. Rats were classified into six groups that were control (+ ve), arginine (100 mg/kg), parsley powder (10% parsley powder), parsley extract (25 mg /kg), parsley powder + arginine (10% parsley powder and 5 g/kg of arginine) and parsley extract with arginine group (25 mg /kg parsley extract with 5 g/kg of
more » ... with 5 g/kg of arginine) rat groups. The study period was 60 days. Results showed that consumption of arginine and parsley group showed improvement of nutritional values and had significant decrease in serum creatinine, urea, uric acid and malondialdehyde. Moreover, they showed significant increase in serum total protein, globulin, hemoglobin, packed cell volume and serum and kidney superoxide dismutase, glutathione-peroxidase and glutathione S-transferase compared with control (+ve) group. The best treatment effect of kidney injured was appeared in parsley powder or extract with arginine groups. These results may be attributed to nutritional component of parsley and antioxidant activity.
doi:10.3109/0886022x.2010.501933 pmid:20722564 fatcat:7t2bpunz5jd6lb5cq3hr2oscya