Primary macular hole is a defect in fovea and is a frequent cause of decrease vision and metamorphopsia. Primary macular Hole (PMH) was first time introduced by Johnson and Gass in 1988. Aims and Objectives: This study aims to evaluate the sub-foveal choroidal thickness in primary macular hole. Materials and Methods: This prospective and controlled study was done at Institute of Ophthalmology, Liaquat University of Medical & Health Sciences, Jamshoro for the period one year. Visual acuity was

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... ecked with Snellen Chart and ophthalmic examination was done with bio-microscopic slit lamp using 90 diopter (D) lens pre-operatively and post-operatively. Swept Source optical coherence tomography (SS-OCT) was used to confirm the diagnosis, outcome of PMH surgery, to measure choroidal thickness of both eyes preoperatively and postoperatively at the end 2nd month. Results: From the selected patients, the average ages was 63 year, ranging between 46 to 80 years and from them 45 were females and 26 were males. 41 were right eye and 30 were left eye. PMH characteristics was used for the determination of duration of symptoms and minimum hole diameter, In 63 patients hole was closed and in 8 patients the hole was opened. The average duration of symptom was 5 months and Average minimum diameter was 320 μm and range was 139-650 μm among the patients with closed hole. Conclusion: Sub-foveal CT was thinner in eyes with PMH as compared to fellow normal eye. But it was not related with anatomical results of PMH surgery. The sub-foveal CT reduced thickness is due to longer duration and larger minimum diameter of PMH.