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Extracellular CIRP Activates the IL-6Rα/STAT3/Cdk5 Pathway in Neurons
Extracellular cold-inducible RNA-binding protein (eCIRP) stimulates microglial inflammation causing neuronal damage during ischemic stroke and is a critical mediator of alcohol-induced cognitive impairment. However, the precise role of eCIRP in mediating neuroinflammation remains unknown. In this study, we report that eCIRP activates neurotoxic cyclin-dependent kinase-5 (Cdk5)/p25 through the induction of IL-6Rα/STAT3 pathway in neurons. Amyloid b (Aβ)-mediated neuronal stress, which isdoi:10.21203/rs.3.rs-212093/v1 fatcat:pwu45bd5ozgzdhf2veci4of6he