Distinct inactivated bacterial-based immune modulators vary in their therapeutic efficacies for treating disease based on the organ site of pathology

Shirin Kalyan, Mark Bazett, Ho Pan Sham, Momir Bosiljcic, Beryl Luk, Salim Dhanji, Amanda M. Costa, Stephanie W. Y. Wong, Mihai G. Netea, David W. Mullins, Hal Gunn
2020 Scientific Reports  
Recent developments in understanding how the functional phenotype of the innate immune system is programmed has led to paradigm-shifting views on immunomodulation. These advances have overturned two long-held dogmas: (1) only adaptive immunity confers immunological memory; and, (2) innate immunity lacks specificity. This work describes the observation that innate immune effector cells appear to be differentially recruited to specific pathological sites when mobilized by distinct inactivated
more » ... erial-based stimuli administered subcutaneously. The studies presented suggest that the immune system, upon detecting the first signs of a potential infection by a specific pathogen, tends to direct its resources to the compartment from which that pathogen is most likely originating. The findings from this work puts forth the novel hypothesis that the immunotherapeutic efficacy of a microbial-based stimulus for innate immune mobilization depends on the correct selection of the microbial species used as the stimulant and its relationship to the organ in which the pathology is present.
doi:10.1038/s41598-020-62735-z pmid:32246043 fatcat:c7ypmp464rcovk3rt72hewouly