Rapid Progression of Hepatocellular Carcinoma in a Patient with Autoimmune Hepatitis

Kayo Yamamoto, Masaaki Hiura, Akinari Tabaru, Yuichi Honma, Ryoichi Narita, Shintaro Abe, Shohei Shimajiri, Kohji Okamoto, Koji Yamaguchi, Masaru Harada
2011 Internal medicine (Tokyo. 1992)  
We describe a case of a 69-year-old woman who developed rapidly progressive hepatocellular carcinoma (HCC) associated with autoimmune hepatitis (AIH) after a 7-year follow-up. Markers for viral hepatitis were negative. Serum tumor markers including alpha-fetoprotein and prothrombin induced by vitamin K absence II rose suddenly, and a large tumor was detected in spite of regular surveillance for HCC. Surgical treatment was performed. The resected liver specimen revealed well to moderately
more » ... ntiated HCC. Ki67 staining showed rapid proliferation of the HCC. Although the incidence of HCC in patients with AIH has been unclarified, the possible complication by HCC must not be overlooked.
doi:10.2169/internalmedicine.50.4873 pmid:21720061 fatcat:zbmjrayimnfd5ppx7f7mkwyvja