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Cardiac abnormalities are the most common birth defects. Derangement of circulatory flow affects many vital organs; without proper supply of oxygenated blood, the brain is particularly vulnerable. Although surgical interventions have greatly reduced mortality rates, patients often suffer an array of neurological deficits throughout life. Neuroimaging provides a macroscopic assessment of brain injury, and has shown that white matter is at risk. Oligodendrocytes and myelinated axons have beendoi:10.1016/j.tins.2015.04.001 pmid:25939892 pmcid:PMC4461528 fatcat:3mrmfmosnnfjrf4e5mk75itkwe