Congenital cardiac anomalies and white matter injury

Paul D. Morton, Nobuyuki Ishibashi, Richard A. Jonas, Vittorio Gallo
2015 Trends in Neurosciences  
Cardiac abnormalities are the most common birth defects. Derangement of circulatory flow affects many vital organs; without proper supply of oxygenated blood, the brain is particularly vulnerable. Although surgical interventions have greatly reduced mortality rates, patients often suffer an array of neurological deficits throughout life. Neuroimaging provides a macroscopic assessment of brain injury, and has shown that white matter is at risk. Oligodendrocytes and myelinated axons have been
more » ... tified as major targets of white matter injury, but still little is known about how congenital heart anomalies affect the brain at the cellular level. Further integration of animal model studies and clinical research will define novel therapeutic targets and new standard of care to prevent developmental delay associated with cardiac abnormalities.
doi:10.1016/j.tins.2015.04.001 pmid:25939892 pmcid:PMC4461528 fatcat:3mrmfmosnnfjrf4e5mk75itkwe