Faculty of 1000 evaluation for Awake replay of remote experiences in the hippocampus [dataset]

Edvard I Moser, Dori Derdikman
2009 F1000 - Post-publication peer review of the biomedical literature   unpublished
Hippocampal replay is thought to be essential for the consolidation of event memories in hippocampal-neocortical networks. Replay is present during both sleep and waking behavior, but while sleep replay involves the reactivation of stored representations in the absence of specific sensory inputs, awake replay is thought to depend on sensory input from the current environment. Here we show that stored representations are reactivated during both waking and sleep replay. We found frequent awake
more » ... lay of sequences of rat hippocampal place cells from a previous experience. This spatially remote replay was as common as local replay of the current environment and was most robust when the animal had recently been in motion as compared to during extended periods of quiescence. These results indicate that the hippocampus consistently replays past experiences during brief pauses in waking behavior, suggesting a role for waking replay in memory consolidation and retrieval. Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms Author Contributions M.K and L.F. designed the experimental paradigm; M.K. carried out all of the data collection and the majority of the analyses; L.F. carried out the remaining analyses; M.K. and L.F. wrote the manuscript.
doi:10.3410/f.1164561.627084 fatcat:byeugqcqhbaupeagnqsbqtodq4