Effects of intensive cognitive-behavioral therapy on cingulate neurochemistry in obsessive–compulsive disorder

Joseph O'Neill, Eda Gorbis, Jamie D. Feusner, Jenny C. Yip, Susanna Chang, Karron M. Maidment, Jennifer G. Levitt, Noriko Salamon, John M. Ringman, Sanjaya Saxena
2013 Journal of Psychiatric Research  
The neurophysiological bases of cognitive-behavioral therapy (CBT) for obsessive-compulsive disorder (OCD) are incompletely understood. Previous studies, though sparse, implicate metabolic changes in pregenual anterior cingulate cortex (pACC) and anterior middle cingulate cortex (aMCC) as neural correlates of response to CBT. The goal of this pilot study was to determine the relationship between levels of the neurochemically interlinked metabolites glutamate + glutamine (Glx) and
more » ... ate + N-acetyl-aspartyl-glutamate (tNAA) in pACC and aMCC to
doi:10.1016/j.jpsychires.2012.11.010 pmid:23290560 pmcid:PMC3672238 fatcat:rkvvxglnhbbmbinguieh6vmllm