Abbreviations: HSC, hepatic stellate cell; ECM, extracellular matrix; MMP, matrix metalloproteinases; TIMP, tissue inhibitors of metalloproteinases; TGF-β, transforming growth factor beta; NASH, non-alcoholic steatohepatis; NKC, natural killer cell; TRAIL, TNFrelated apoptosis inducing ligand J Liver Res Disord Ther. 2016;2(2):36-39. 36 Abstract Excessive hepatic fibrosis leading towards the cirrhosis is the major determinant of morbidity and mortality in chronic liver disease patients. The

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... rsing hepatic fibrosis has been intensively studied and fuelled up the hope in development of effective and targeted antifibrotic therapy in upcoming years. There are four pillars of pharmacological approach in regression of fibrosis-cessation of damage, the changes in pro-fibrogenic microenvironment, deactivation of activated hepatic stellate cells and degradation of ECM. In this review, we are going to discuss therapeutic concepts and estimate the leading candidate antifibrotic therapy to be introduced in the intervention of hepatic fibrosis.