Therapeutic Alliance: Using N-(2,3,4,5,6-Pentahydroxylhex-1-yl)-NDithiocarbamate-L-Isoleucine Disodium to Improve the Toxicity and Survival of Cisplatin Receiving Mice

Yuji Wang, Ming Zhao, Guohui Cui, Chunying Cui, Jingfang Ju, Shiqi Peng
2008 The Open Toxicology Journal  
To reduce the toxicity of cisplatin N-(2,3,4,5,6-pentahydroxylhex-1-yl)-N-dithiocarbamate-L-isoleucine disodium (GID) based therapeutic alliance is investigated. For the proliferation of HepG 2 , Hela, MES-SA, HL 60 and H1299 cells, 27μM of GID based therapeutic alliance gave comparable inhibition to cisplatin alone. For implanted tumor proliferation in mice, 1.667μmol/kg of GID based therapeutic alliance gave higher inhibition than cisplatin alone. For cisplatin receiving mice, this
more » ... ce, this therapeutic alliance effectively reduces the platinum accumulations in the organs but does not affect the platinum level in the tumor tissue. Comparing to cisplatin alone, this therapeutic alliance not only increases urea and fecal platinum levels but also increases urea excretion. All the observations imply that GID based therapeutic alliance is capable of reducing the toxicity and supporting the anti-tumor potency of cisplatin.
doi:10.2174/1874340400802010001 fatcat:gjhkungy2fe2vaflfi4ivhcsce