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Asian Journal of Biomedical and Pharmaceutical Sciences
Anew series of novel 1,3,4-oxadiazoles derivatives have been synthesized by linear synthetic method and screened these compounds for anticancer activity on HeLa, MCF7, Caco-2 cell lines. Final 1, 3, 4-oxadiazoles 6a-6f were characterized by LCMS,1H NMR,13C, and elemental analysis. Oxidative cyclisation reaction of the corresponding key intermediate Schiff base derivatives 5a-5f yielded the desired novel 1, 3, 4-oxadiazoles. Most of the compounds in this series showed moderate cytotoxicity ondoi:10.15272/ajbps.v4i37.521 fatcat:ubcsxnjx5bcz7ok4xl42dryydi